| 30.04.2022 | Hillerod vs B.93 | GG | 1.50 | 3 : 2  |
| 30.04.2022 | Bristol City vs Hull | 1 | 2.10 | 5 : 0 |
| 30.04.2022 | Viking vs Haugesund | Over 2.5 | 1.55 | 5 : 1 |
| 29.04.2022 | Annecy vs Sete | GG | 2.10 | 3 : 0  |
| 29.04.2022 | St. Pauli vs Nurnberg | 1 | 1.85 | 1 : 1 |
| 29.04.2022 | Fredrikstad (Nor) vs Odd (Nor) | Over 2.5 | 1.45 | 0 : 2 |
| 25.04.2022 | Brondby vs Midtjylland | 2 | 2.25 | 1 : 3 |
| 25.04.2022 | Honka vs SJK | GG | 1.80 | 5 : 1 |
| 25.04.2022 | Laval vs Boulogne | 1 | 1.50 | 1 : 0 |
| 24.04.2022 | Banfield vs Talleres Cordoba | 1 | 2.15 | 3 : 1 |
| 24.04.2022 | Adelaide United vs Perth Glory | 1 | 1.40 | 2 : 0 |
| 24.04.2022 | Plzen vs Slovacko | Over 2.5 | 1.70 | 3 : 1 |
| 23.04.2022 | Dornbirn vs Lafnitz | 2 | 1.75 | 1 : 4 |
| 23.04.2022 | Wilstermann vs Universitario de Vinto | 1 | 1.70 | 1 : 1 |
| 23.04.2022 | Portsmouth vs Gillingham | 1 | 1.80 | 3 : 1 |
| 22.04.2022 | Vorwarts Steyr vs Floridsdorfer AC | 2 | 2.05 | 1 : 0 |
| 22.04.2022 | Karlsruher SC vs Ingolstadt | 1 | 1.90 | 2 : 2 |
| 22.04.2022 | St. Patricks vs Finn Harps | 1 | 1.60 | 2 : 0 |
| 19.04.2022 | Villarreal vs Valencia | 1 | 1.40 | 2 : 0 |
| 19.04.2022 | Western United vs Macarthur FC | 1 | 1.95 | 2 : 0 |
| 19.04.2022 | Union La Calera vs O’Higgins | GG | 1.75 | 0 : 0 |
| 17.04.2022 | Flamengo RJ vs Sao Paulo | 1 | 1.70 | 3 : 1 |
| 17.04.2022 | Bragantino vs Atletico GO | 1 | 1.85 | 4 : 0 |
| 17.04.2022 | Rio Ave vs Benfica B | 1 | 1.75 | 2 : 1 |
| 16.04.2022 | Once Caldas vs Cortulua | 1 | 1.55 | 1 : 0 |
| 16.04.2022 | Rodez vs Paris FC | 2 | 2.25 | 0 : 1 |
| 16.04.2022 | Sandhausen vs St. Pauli | GG | 1.60 | 1 : 1 |
| 15.04.2022 | Dornbirn vs Liefering | 2 | 1.65 | 1 : 4 |
| 15.04.2022 | Koge vs F. Amager | GG | 1.70 | 1 : 1 |
| 15.04.2022 | Birmingham vs Coventry | 2 | 2.00 | 2 : 4 |
| 11.04.2022 | Halmstad vs Norrby | 1 | 1.80 | 1 : 2 |
| 11.04.2022 | Malmo FF vs Elfsborg | GG | 1.70 | 1 : 1 |
| 11.04.2022 | Brescia vs Parma | GG | 1.85 | 1 : 0 |
| 10.04.2022 | Genoa vs Lazio | 2 | 2.10 | 1 : 4 |
| 10.04.2022 | Rapid Vienna vs Wolfsberger AC | Over 2.5 | 1.80 | 2 : 1 |
| 10.04.2022 | Atletico-MG vs Internacional | 1 | 1.55 | 2 : 0 |
| 09.04.2022 | RWDM vs Waasland-Beveren | 1 | 2.15 | 2 : 1 |
| 09.04.2022 | D. Puerto Montt vs Recoleta | 1 | 1.55 | 1 : 0 |
| 09.04.2022 | Aberdeen vs Ross County | 1 | 1.75 | 0 : 1 |
| 08.04.2022 | Lorient vs St Etienne | 1 | 2.25 | 6 : 2 |
| 08.04.2022 | BW Linz vs Amstetten | 1 | 1.40 | 5 : 2 |
| 08.04.2022 | Den Bosch vs Dordrecht | Over 2.5 | 1.55 | 3 : 0 |
| 05.04.2022 | ADR Jicaral vs Herediano | 2 | 1.85 | 0 : 3 |
| 05.04.2022 | Cambridge Utd vs Wycombe | GG | 1.80 | 1 : 4 |
| 05.04.2022 | Spal vs Cosenza | 1 | 1.80 | 2 : 2 |
| 03.04.2022 | Brescia vs L.R. Vicenza | 1 | 1.55 | 2 : 0 |
| 03.04.2022 | Bodo/Glimt vs Rosenborg | 1 | 1.55 | 2 : 2 |
| 03.04.2022 | FCSB vs Univ. Craiova | 1 | 2.10 | 0 : 2 |
| 02.04.2022 | Dortmund vs RB Leipzig | Over 2.5 | 1.55 | 1 : 4 |
| 02.04.2022 | Lazio vs Sassuolo | 1 | 1.55 | 2 : 1 |
| 02.04.2022 | Luton vs Millwall | 1 | 2.15 | 2 : 2 |
| 01.04.2022 | Villefranche vs Cholet | 1 | 1.60 | 3 : 2 |
| 01.04.2022 | Galway vs Cobh Ramblers | 1 | 1.55 | 4 : 1 |
| 01.04.2022 | Salford vs Crawley | Over 3.5 | 2.20 | 1 : 2 |
